Endocrine Abstracts

Cushing’s syndrome, whether it is ACTH-dependent or ACTH-independent, causes many complications due to chronic exposure of tissues to a glucocorticoid excess. Some of these are arterial hypertension, obesity, osteoporosis, coagulopathies, impaired glucose tolerance and diabetes. We present a case of Cushing’s syndrome diagnosed in a 64-year-old female that was referred to the Endocrinology Department from the Physical Medicine and Rehabilitation Department due to mul...

Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.<p class=...

Introduction: Thyroid cancer in childhood and adolescence represents 1.5–3% of all carcinomas in this group of age. Our purpose is to define clinical and pathological features, therapeutical complications and follow-up characteristics and survival of a group of children and adolescents with thyroid carcinomas.Design: We report a retrospective study of 26 children and adolescents with thyroid carcinoma who were investigated in our institution from Ja...

Medullary thyroid carcinoma (MTC) is a rare malignancy arising from parafollicular C cells of the thyroid gland, sometimes due to germline mutations in the RET protooncogene. Testicular cancer is the most common malignancy in men aged 15 - 40 years with survival rates improved by the introduction of cisplatin therapy in the late 1970s. Nonetheless, platinum-based chemotherapy was shown to increase the risk of a solid second cancer with substantially increased site-specific ris...

Introduction: Ectopic ACTH syndromes account for 5–10% of Cushing syndrome, with intrathoracic and gastrointestinal–pancreatic neuroendocrine tumors being the most common causes, followed by small cell lung cancer, adrenal paraganglioma and medullary thyroid carcinoma.Case report: A 50-year-old male hypertensive and diabetic patient was transferred to our clinic for emergency endocrine care for hypokalemia. He had mild hypercortisolism and live...

Background: Dopamine agonists (DAs) were associated with valvular dysfunction in patients with Parkinson’s disease due to their fibrotic effect through the serotoninergic receptor. It is more difficult to prove the same effects in patients with prolactinoma due to the lower doses, variable doses and the longer follow-up period. Aim: To assess echocardiographic features in patients with prolactinoma under DA treatment.Methods: ...

Introduction: We describe the case of a 68-year-old patient, having two MEN1-associated tumors that are not part of the classical triad, with a penetrance of only 40%, and 2%, according to the medical literature. Furthermore, she developed a persistent hyperkalemia after the unilateral adrenalectomy, which is rare and often missed.Case report: In 2011, following a non-specific symptomatology (dry cough, fatigue), a bilobectomy was performed (medium and r...

Introduction: Diagnostic imaging of neuroendocrine tumors (NETs) is the domain of somatostatin receptor (SSTR) agonists as well as FDG PET/CT in dedifferentiated tumors. SSTR also serves as target for receptor directed peptide therapy. More recently, specific ligands targeting the chemokine receptor 4 (CXCR4) were introduced potentially offering an additional theranostic option in NETs. Here we evaluated the CXCR4 expression using 68Ga-Pentixafor PET/CT in NET patie...

Introduction: The epidemic of obesity has risen many health concerns, beneath the metabolic syndrome. One of these problems is the effect of obesity on cancer evolution. Populational studies have shown a direct correlation of BMI with worse prognostic, life quality and occurrence of comorbidities in neoplastic diseases, one of the most studied being breast cancer.Patients and methods: We retrospectively analysed the evolution of postmenopausal obese and ...

Erdheim-Chester disease (ECD) is a rare histiocytic neoplasm with distinctive clinical and immunophenotypic features, involving somatic mutations of BRAF and activation of MAPK pathway. Other BRAF mutated neoplasms such as papillary thyroid carcinoma (PTC), may also occur synchronous with EDC. There are several reports in the literature of concurrent Langerhans Cell Histiocytosis (LCH) and PTC which suggests that the association is not random, howeve...